Plant secondary metabolites against Candida auris: mechanisms and evidence

Holanda de Sousa, Silvana Y Ferreira de Sousa, Odaiza Y Cardoso Jurema, Hallye Y Silva Campos, Tales Guilherme Y León Rodríguez, César Elías Y Soares da Silva, Marília Pantoja Y Beatriz Silva, Vitória Y Rodrigues Cangussu, Alex Sander Y de Souza Aguiar, Raimundo Wagner Y dos Santos, Gil Rodrigues Y Gontijo da Silva, Marcos (2026) Plant secondary metabolites against Candida auris: mechanisms and evidence. Revista de Ciencias Agr�colas, 43 (1). e1295. ISSN 2256-2273

Text v43n1a13.pdf Download (1MB)

Resumen

Candida auris is an emerging multidrug-resistant fungal pathogen that poses a significant public health threat. This fungus has spread to more than 30 countries. This review was conducted aiming to search for in vitro studies on the antifungal actions of plant metabolites against C. auris. The review was constructed following the guidelines of the PRISMA statement. The research protocol was registered on the PROSPERO platform. A literature search was performed in the PubMed, Scopus, and Virtual Health Library databases, with no restrictions on year or language. Eligibility criteria were based on the PICO concept. Data were meta-analyzed using R software. The risk of bias assessment was performed using an adaptation of the CONSORT tool. A total of 11 of the 768 articles were included in the systematic review and meta-analysis, and 30 secondary metabolites of plant origin were analyzed. Of the 30 metabolites found, 26 presented results similar to the controls, and 4 showed superior results: palm leaf extract, Syzygium samarangense bark, Cinnamomum zeylanicum oil (bark) and Cinnamomum zeylanicum (leaf). Most plant secondary metabolites showed excellent antifungal potential against C. auris. As a limitation of the study, metabolites of very heterogeneous origin, extraction method, and distinct controls were grouped, which may have interfered with the interpretation of the results, increasing the risk of bias and imprecision. Therefore, further research is needed to confirm their clinical efficacy and safety and elucidate the mechanisms of action.

Tipo de Elemento:	Artículo
Palabras Clave:	antifungal activity; bioactive compounds; essential oils; fungal pathogens; natural extracts; phytochemicals
Asunto:	S Agricultura > S Agriculture (General)
Division:	Revistas > Revista de Ciencias Agrícolas
Depósito de Usuario:	FACIA Fac. Ciencias Agrícolas Udenar
Fecha Deposito:	15 Sep 2026 16:22
Ultima Modificación:	15 Sep 2026 16:22
URI:	http://sired.udenar.edu.co/id/eprint/18794

Ver Elemento