Síntesis de Piridazin-3(2H)-onas asistida por Microondas en Condiciones Libre de Disolvente

Cruz, Silvia Y Cifuentes, Diego Y Hurtado, Nelson Y Roman, Maritza (2016) Síntesis de Piridazin-3(2H)-onas asistida por Microondas en Condiciones Libre de Disolvente. Información Tecnológica, 27 (5). pp. 57-62. ISSN 0718-0764

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Resumen

The synthesis of a series of pyridazin-3(2H)-ones and cinnolin-3,5-dione in the reaction of acetophenones p-substituted or dimedone with glyoxilic acid and hydrazine hydrate under microwave irradiation and solvent-free conditions is described. Pyridazinones are nitrogenated heterocyclic compound synthetically produced which have been systematically studied due to their promising biological and pharmacological activity. The structure of the products is based on detailed NMR analysis of experiments such as 1H, 13C, HSQC, HMBC and mass spectrometry. This methodology leads to good yields in short reaction times. This is of especial interest from the environmental point of view.

Tipo de Elemento: Artículo
Palabras Clave: piridazinona; cinolina; reacciones inducidas; irradiación con microondas; reacciones onepot
Asunto: Q Ciencias > QD Chemistry
Division: Facultad de Ciencias Exactas y Naturales > Programa de Química > Productividad
Depósito de Usuario: PhD NELSON HUMBERTO HURTADO GUTIERREZ
Fecha Deposito: 30 Jan 2017 22:05
Ultima Modificación: 30 Jan 2017 22:05
URI: http://sired.udenar.edu.co/id/eprint/3587

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