Solvent-Free Microwave-Assisted Synthesis of Novel 4-Hetarylpyrazolo[1,5-a][1,3,5]triazines

Insuasty, Henry Y Estrada, Sandra Y Quiroga, Jairo Y Insuasty, Braulio Y Abonía, Rodrigo Y Nogueras, Manuel Y Cobo, Justo (2012) Solvent-Free Microwave-Assisted Synthesis of Novel 4-Hetarylpyrazolo[1,5-a][1,3,5]triazines. Journal of Heterocyclic Chemistry, 49 (6). pp. 1339-1345. ISSN 1943-5193

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URL Oficial: http://onlinelibrary.wiley.com/doi/10.1002/jhet.97...

Resumen

A series of novel 4-hetaryl substituted pyrazolo[1,5-a][1,3,5]triazines were synthesized by microwave assisted reaction betweenO,S-diethyl hetaroylimidothiocarbonates and 5-amino-3-aryl-1H-pyrazoles under solvent-free conditions. This procedure led to the formation of mixtures of two new pyrazolotriazine derivatives in a 1:4 ratio, which were separated by column chromatography being their corresponding structures unambiguously established by spectroscopic and analytical techniques. Comparison of the reactions mediated by microwave irradiation and by conventional heating in solution of DMF showed that both procedures afforded the same mixtures of products, but thefirst approach required shorter reaction times and gave higher yields than the second one.

Tipo de Elemento: Artículo
Palabras Clave: pyrazolo[1,5-a][1,3,5]triazines heterocyclic compounds
Asunto: Q Ciencias > QD Chemistry
Division: Facultad de Ciencias Exactas y Naturales > Programa de Química > Productividad
Depósito de Usuario: doctor HENRY INSUASTY
Fecha Deposito: 31 Jan 2017 22:57
Ultima Modificación: 31 Jan 2017 22:57
URI: http://sired.udenar.edu.co/id/eprint/3672

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