Insuasty, Henry Y Insuasty, Braulio Y Castro, Edison Y Quiroga, Jairo Y Abonía, Rodrigo Y Nogueras, Manuel Y Cobo, Justo (2012) Three practical approaches for the synthesis of novel 4,7-dihetarylpyrazolo[1,5-a] [1,3,5]triazines. Tetrahedron Letters, 68 (-). pp. 9384-9390. ISSN 0040-4039
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Novel 4,7-dihetarylpyrazolo[1,5-a][1,3,5]triazines were synthesized from three different approaches. The first one, involved a one-step reaction between 5-amino-3-hetaryl-1H-pyrazoles andO,S-diethyl hetar-oylimidothiocarbonates or S,S-diethyl hetaroylimidodithiocarbonates under solvent-free conditions employing microwave irradiation as the energy source. In the second approach, conventional heating under reflux in DMF as solvent was used instead of the microwave irradiation; and the third one was achieved from a two-step sequence through the treatment of 5-amino-3-hetaryl-1H-pyrazoles with hetaroyl isothiocyanates and the subsequent S-alkylation and cyclization process in DMF as solvent. Some intermediates were isolated and characterized to support the regiochemistry of the studied re-actions. The structures of the new compounds were unambiguously established by spectroscopic and analytical techniques
| Tipo de Elemento: | Artículo |
|---|---|
| Palabras Clave: | Pyrazolo[1,5-a][1,3,5]triazines O,S-Diethyl hetaroylimidothiocarbonates S,S-Diethyl hetaroylimidodithiocarbonates 5-Amino-1H-pyrazoles Pyrazolylthioureas |
| Asunto: | Q Ciencias > QD Chemistry |
| Division: | Facultad de Ciencias Exactas y Naturales > Programa de Química > Productividad |
| Depósito de Usuario: | doctor HENRY INSUASTY |
| Fecha Deposito: | 31 Jan 2017 22:53 |
| Ultima Modificación: | 31 Jan 2017 22:53 |
| URI: | http://sired.udenar.edu.co/id/eprint/3665 |
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